SP OXYMETABOL

Indications:

Oxymetabol is indicated in protein synthesis disorders, cachexia of diverse genesis; trauma, extensive burns after irradiation and infectious diseases; muscular dystrophy, osteoporosis, negative nitrogen balance corticosteroid therapy, hypo and aplastic anemia.

Contra- indications:

This medicine is not indicated if patients suffer from hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, severe atherosclerosis, nephritis, nephrotic syndrome, hepatic and renal failure, acute and chronic prostatitis, pregnancy, lactation.

Administration:

The recommended daily dose for adults and children is 1-5 mg / kg / day. The usual effective dose is 1-2 mg / kg / day, but can be used higher doses, though the administered dose depends on each individual. The result is not felt immediately, so the treatment lasts at least 3-6 months minimum. Patients with congenital aplastic anemia may require a continuous treatment with a maintenance dose.

Medical action:

Oxymetholone is an anabolic steroid. Getting into the cell nucleus it stimulates the genetic apparatus of the cell, which causes an increased synthesis of DNA, RNA and structural proteins, stimulates respiration tissue chain enzymes and enhances respiration tissue, oxidative phosphorylation, ATP synthesis and intracellular macroergic aggregation. This medicine stimulates anabolic processes and inhibits the catabolic ones caused by glucocorticoids. Oxymetholone can cause increased muscle mass, reduced fat deposits, improves trophic tissues, promotes calcium deposition in bones, retains water in the body. The hematopoietic process is determined by the increased level of erythropoietin synthesis. The androgenic effect may cause the development of male secondary sexual characteristics.

Precautions:

In case you feel first signs of virilization (deepening of the voice, hirsutism, acne, clitoromegaly) stop taking this medicine in order to avoid unwanted side effects. It may occur the suppression of plasma coagulation factors II, VII, VII and X and increases the prothrombin time. A systematic monitoring of lipidemic and cholesterol level is needed. The pediatric use must be done by an experienced specialist to avoid premature epiphyseal bone calcification.

Side effects:

Oxymetholone can cause different side effects in women and men. They present different symptoms in men and women, but can be the same in some cases.

Women – virilizing signs, inhibition of ovarian function, menstrual disorders, hypercalcemia.

Men: in prepubertal – virilization symptoms, skin hyperpigmentation idiopathic withholding or stopping the growth (calcification of epiphyseal growth zones of tubular bones); during postpubertal – bladder irritation, gynecomastia, priapism; in the elderly – hypertrophy and / or prostatic carcinoma.

Both men and women – the progression of atherosclerosis, peripheral edema, impaired liver function with jaundice, changes in blood count, long tubular bones pain, hypo coagulation prone to bleeding.

Overdosage:In case, an overdose with Oxymetholone happened seek emergency help.